Detecting non-germinomatous germ cell tumor component by arterial spin labeling perfusion-weighted MR imaging in central nervous system germ cell tumor

Purpose Differentiating between germinoma and non-germinomatous germ cell tumor (NGGCT) is important because sensitivity to chemotherapy and/or radiotherapy quite different these two subgroups. In this study, we evaluated whether the arterial spin labeling (ASL) based perfusion-weighted imaging (PWI) could provide additional information for differential diagnosis NGGCT. Method Between 2011 2018, 20 patients with central nervous system (CNS) (GCT) who underwent preoperative MR including ASL-PWI were enrolled in study. Relative blood flow (rTBF) was on by manually placing regions of interest at gadolinium enhanced part tumors normal subcortical white matter. Presence intratumoral T1 hyperintense foci apparent diffusion coefficient (ADC) also evaluated. The final made combination markers histological diagnosis. Results Among CNS-GCT, 11 diagnosed as 9 subgroup, rTBF ranged from 0.90 1.71 (mean 1.21, median 1.09), while it 1.14 5.75 3.91, 3.31) NGGCT subgroup. receiver operating characteristic (ROC) curve showed that calculating useful differentiating (area under (AUC) 0.929, P = 0.0012) compared (AUC 0.788, 0.0304) ADC 0.919, 0.0016). Conclusions High obtained implied presence component. This might help deciding chemotherapy/radiotherapy intensity.